When neurons are lost to degeneration the resulting disability is permanent. That is because the mammalian nervous system lacks the ability to regenerate neurons. Our lab develops strategies to reprogram Muller glia into a source for neuronal replacement in the retina. It was first shown that overexpression of Ascl1, a proneural transcription factor, was capable of reprogramming Muller glia into functional neurons in vivo in the adult mouse retina. We have since found methods to improve the neurogenesis from glia as well as steer regenerated neurons to cell types of choice. Our lab continues to seek ways to enhance regeneration strategies in the mammalian retina in hopes of developing future cell replacement therapies in neurodegenerative disorders.